- The interception of the wireless transmission and the fake horoscopes handed out in class are taken from James Randi's actual work of exposing frauds.
- The scene in which Margaret Matheson exposes a psychic healer by listening in on a partner feeding him instructions wirelessly was based on the case in which skeptics James Randi and Steve Shaw (better known under his stage name Banachek), with technical assistance from crime scene analyst and electronics expert Alexander Jason, exposed Peter Popoff in 1986. In that case, as in the scene, Popoff's wife Elizabeth was feeding him information that she and her aides had taken from prayer request cards filled out by audience members over wireless radio. Some of the dialogue is taken almost verbatim from the actual case. In May 1986, Randi presented the evidence on The Tonight Show Starring Johnny Carson (1962), exposing Popoff's fraudulent practices. In 1987, Popoff declared bankruptcy, only to make a comeback in the late 1990s and early 2000s.
- Sally Owen: How did you know that?
Tom Buckley: Because I'm psychic.
Filming occurred in Spain and Canada, with ten of the filming locations based in Barcelona, Spain; a week of filming was undertaken at the Fairmont Royal York in Toronto, Canada and significant shots were taken on James Street North in nearby Hamilton, Canada. The filming process for Red Lights commenced in February 2011 and concluded in April 2011.
The film premiered at the Sundance Film Festival in January 2012, and received a limited release in the United States on 13 July 2012.